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Influences of diabetes on hearing recovery in noise-exposed mice
©öDepartment of Otorhinolaryngology-Head & Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; ©÷Asan Institute For Life Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Chan Joo Yang©ö, Ji-Won Lee©÷, Jong Woo Chung©ö
¸ñÀû: Many studies have reported an association between diabetes and hearing loss. However reports were mainly abstractive correlation of common hearing loss and incidence of diabetes. Therefore, we conducted this study to evaluate the impact of diabetes on occurrence and recovery of noise-induced hearing loss. ¹æ¹ý:We used 5 week-old male mice of C57BLKS/J-m wild type (+/+) as a control group and of C57BLKS/J-db/db as a diabetic group. The hearing levels of both groups were measured weekly for 7 weeks. Both groups were exposed to broad band white noise of 110 dB SPL for 3 hours, and the hearing levels were analyzed before and after the noise exposure. °á°ú:The hearing levels of control group were better than diabetic group at each week for 7 weeks at all ABR frequencies (4, 8, 16, and 32kHz). Both groups showed a threshold increase of hearing level immediately after noise exposure, and began to recover at all frequencies. There was no difference in recovery rate of hearing level between two groups. °á·Ð:This study shows that hearing level significantly was impaired earlier in the diabetic group, compared to normal group. Hearing recovery after noise exposure was similar in diabetic and control mice.


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