목적: Korean red ginseng (KRG) has been shown to have multiple pharmacological activities. Here, we investigated the effects of KRG on rhinovirus (RV) infection in primary human nasal epithelial cells (HNE). 방법:After RV infection and subsequent treatment with KRG, mRNA expression and protein secretion of inflammatory cytokines interleukin-8 (IL-8) and IL-6 were measured by real-time PCR and Enzyme-linked immunosorbent assays. Viral titer assay and western blot for the expression of rhinovirus 3C protease were used to evaluate viral replication in RV-infected cells. The expression mRNA and protein of TLR3 were measured by real-time PCR and western blot analysis. 결과:KRG significantly reduced RV-induced up-regulation of inflammatory cytokines IL-8 and IL-6 mRNA levels and protein secretion and viral replication in primary human nasal epithelial cells. In addition, KRG inhibited the expression of Toll-like receptor (TLR)3 mRNA and protein levels. 결론:These results suggested that treatment of KRG could attenuate the inflammatory responses by human rhinovirus infection, thus may be a potential therapy for prevention of rhinovirus-induced asthma exacerbation.