Hemophagocytic lymphohistiocytosis(HLH) is a rare, potentially fatal hematologic disease featuring ineffective immunity characterized by an uncontrolled hyperinflammatory response. HLH manifests fever, hepatosplenomegaly, lymphadenopathy. It is classified as primary HLH, related to mutation of PRF1, UNC13D or STX11 gene and secondary HLH, related to viral infection. Its treatment includes immunosuppressive agents, biological response modifiers and subsequent stem-cell transplantation. We report a case of 18-year old female with fever, neck mass and mild sore throat, diagnosed with HLH following an EBV infection.