목적: In this study, we investigated the effect of PFF-A and dieckol on the consequences of noise ex-posure in mice. 방법:A total of 46 six-week-old male C57BL/6 mice were randomly assigned to the following groups: Saline (n = 6), Sa-line + Noise (n = 8), PFF-A (10 mg/kg) + Noise (n = 8), High PFF-A (100 mg/kg) + Noise (n = 8), Dieckol (10 mg/kg) + Noise (n = 8), and High- dieckol (100 mg/kg) + Noise (n = 8). Auditory brainstem response threshold, outer hair cell count were measured 4hr, 1 day and 3 days after noise exposure. An F-test followed by student's T-test using SPSS software (ver. 25, IBM) was performed. A p-value of < 0.05 was considered statistically significant. 결과:In 1,1-diphenyl-2-picrylhydrazyl assay, dieckol and PFF-A both showed significant radi-cal-scavenging activity. The mice were exposed to 115 dB SPL of noise one single time for 2 h. Auditory brainstem response(ABR) threshold shifts 4 hours after 4 kHz noise ex-posure in mice that received dieckol were significantly lower than those in the saline with noise group. The high-PFF-A group showed a lower threshold shift at click and 16 kHz 1 day after noise exposure than the control group. The high-PFF-A group also showed higher hair cell sur-vival than in the control at 3 days after exposure in the apical turn. 결론:These results suggest that noise-induced hair cell damage in cochlear and the ABR threshold shift can be alleviated by dieckol and PFF-A in the mouse. Derivatives of these compounds may be applied to individuals who are inevitably exposed to noise, contributing to the prevention of noise-induced hearing loss with a low probability of adverse effects.