목적: In this study, we attempted to analyze the treatment results of head and neck squamous cell carcinoma (HNSCC) patients who underwent curative surgery after neoadjuvant immunotherapy, and to investigate the effects on postoperative complications, mortality, and surgical outcomes. 방법:From December 2018 to December 2020, a total of 36 HNSCC patients underwent curative surgery after neoadjuvant immunotherapy. We retrospectively analyzed the medical records of those patients. 결과:The average operation time was 315 minutes and the average bleeding volume was 167cc. The average length of hospital stay for patients was 21 days. When evaluating the status of surgical margin, 12 patients (33.3%) had a positive margin and 24 patients (66.6%) showed a negative margin. There was no case where surgery was impossible due to hyperprogression of the lesion during the period of neoadjuvant immunotherapy. The postoperative complication rate was 19.4%, and there were 3 cases of pneumonia, 1 case of seroma, 1 case of hematoma, and 2 cases of pharyngeal fistula. There was no case of death due to complications or other complications during the recovery period after surgery. 결론:In patients with HNSCC after neoadjuvant immunotherapy, there was no increase in the incidence of complications related to curative surgery and no increase in the number of deaths. It is believed that this treatment protocol can be performed relatively safely for HNSCC patients.