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접수번호 - 270182 5 |
| ASSOCIATION BETWEEN SEPTAL DEVIATION AND OSA DIAGNOSES: A NATIONWIDE 9-
YEAR FOLLOW-UP COHORT STUDY |
| 1DEPARTMENT OF OTOLARYNGOLOGY-HEAD AND NECK SURGERY, COLLEGE OF MEDICINE, JEONBUK NATIONAL UNIVERSITY, JEONJU, REPUBLIC OF KOREA 2RESEARCH INSTITUTE OF CLINICAL MEDICINE OF JEONBUK NATIONAL UNIVERSITYBIOMEDICAL RESEARCH INSTITUTE OF JEONBUK NATIONAL UNIVERSITY HOSPITAL, JEONJU, REPUBLIC OF KOREA 3DEPARTMENT OF PSYCHIATRY, COLLEGE OF MEDICINE, JEONBUK NATIONAL UNIVERSITY, JEONJU, REPUBLIC OF KOREA 4DEPARTMENT OF MEDICAL INFORMATICS, JEONBUK NATIONAL UNIVERSITY, JEONJU, REPUBLIC OF KOREA 5DEPARTMENT OF PHARMACOLOGY, JEONBUK NATIONAL UNIVERSITY, JEONJU, REPUBLIC OF KOREA 6DIRECTOR OF BIG-DATA CENTER, NATIONAL HEALTH INSURANCE SERVICE (NHIS), WONJU, REPUBLIC OF KOREA 7DEPARTMENT OF FORENSIC MEDICINE, COLLEGE OF MEDICINE, JEONBUK NATIONAL UNIVERSITY, JEONJU, REPUBLIC OF KOREA 8DEPARTMENT OF INTERNAL MEDICINE, DIVISION OF ALLERGY AND PULMONOLOGY, PRESBYTERIAN MEDICAL CENTER, JEONJU, REPUBLIC OF KOREA |
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SANG WOO YEOM, MS1,4*, SANG KEUN CHUNG2,3*, EUN JUNG LEE, MD, PHD1,2*, MIN GUL KIM, MD, PHD2,4,5*, DOO HWAN KIM, MD6*, SANG JAE NOH, MD, PHD2,7, MIN HEE LEE, MD8, YUN NA YANG, MD1, CHAN MI LEE, MD1, JONG SEUNG KIM, MD, PHD1,2,4† |
목적: Obstructive sleep apnea (OSA) is a multilevel problematic disease.
Major septal deviation (SD) can lead to severe nasal congestion, which
in turn can lead to sleep apnea. Although SD seems to be related to
OSA, very few studies have quantitatively examined this relationship.
In this study, we investigate this using a 9-year large-scale cohort
study.
방법:The SD group was selected out of 1 million individuals randomly
extracted by the National Health Insurance Service (NHIS). The non-SD
group was obtained through Propensity Score (PS) matching considering
several variables. The primary end point was OSA diagnosis. 결과:The study (SD) group included 11238 individuals and the non-SD group
(control group) included 22476 persons. The overall hazard ratio (HR)
for OSA in the SD group was 4.39 (95% CI: 3.56–5.42). In subgroup
analysis, the HR for OSA of male individuals was 3.77 (95% CI: 2.83–
5.03), high economic status was 1.27 (95% CI: 1.05–1.56), metropolitan
area was 1.31 (95% CI: 1.07–1.62), young age was 0.79 (95% CI: 0.64–
0.98), hypertension (HTN) was 1.00 (95% CI: 0.37–2.7), and diabetes
mellitus (DM) was 2.44 (95% CI: 1.15–5.21). In the SD group, the HR for
OSA after septoplasty was 0.71 (95% CI: 0.54–0.94). 결론:From long-term follow-up, the prevalence of OSA was 4.39 times higher in
the SD group compared with the control group. This phenomenon was more
pronounced with increasing body mass index (BMI) and decreased
significantly after septoplasty. |
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