목적: It is suggested that deviated nasal septum (DNS) is associated with nonspecific mucosal inflammation due to altered airflow. The authors hypothesized that correction of septal deviation and subsequent improvement in nasal airflow may improve inflammation on the nasal mucosa. To test our hypothesis, we aimed to evaluate the impact of septoplasty on the nonspecific inflammation of the nasal mucosa by measuring the various inflammatory cytokines and biomarkers in the nasal secretion following septoplasty. 방법:17 patients with symptomatic DNS undergoing elective septoplasty were recruited for the study. Symptomatic changes were evaluated using the SNOT-22 and NOSE scores. Using acoustic rhinometry, postoperative changes of the nasal airway volume were measured. Nasal secretion collection was achieved in both pre-operative period and 3-months after septoplasty. The concentration of inflammatory biomarkers HMGB1 and VIP, and inflammatory cytokines including TNF-α, IFN-γ, IL-4, eotaxin, and RANTES were quantified by ELISA and multiplex bead array assays. 결과:The mean age of patients was 30.5, with a male to female ratio of 15 to 2. The median SNOT-22 scores decreased significantly from 54 to 14 after septoplasty.In acoustic rhinometry, nasal cavity volume of the convex side showed a significant increase following septoplasty and the significant discrepancy of nasal airway volume between the concave and convex side became less obvious following septoplasty. Between the concave and convex sides, no significant differences in all cytokine concentrations were shown regardless of preoperative and postoperative conditions. A significant decrease in HMGB1, RANTES, IL-4, and TNF-α concentration were observed at the concave side of the nasal cavity on 3-months post-operative nasal secretion. 결론:Correction of DNS may have a beneficial effect not only on normalizing the nasal airflow and symptom improvement, but also on improving the nonspecific inflammation in the nasal airway.