목적: The cochlear basilar membrane forms the floor of the organ of Corti. When a sound wave is transmitted into the cochlear. The bailar membrane vibrates. The constituent collagen fibers of the basilar membrane affect its stiffness. LOXL2 gene encodes the Lysyl oxidase homolog 2 enzyme. The prototypic member of the lysyl oxidase gene family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase thatcatalyses the first step in the formation of crosslinks in collagen and elastin. This present study aimed to investigate the association of polymorphism at LOXL2 sudden deafness in Korean population. 방법:Study Design: Case-control study. Eighty one Korean SD patients and 455 normal patients (controls) were used in this study. Methods: Single nucleotide polymorphism (SNP) of LOXL2 gene (rs101****, rs1422*****, rs101*****, rs70*****) was analyzed. 결과:At rs101**** and rs 101*****, SNP decrease risk of SD(p<0.05). At rs1442***** and rs 70*****, SNP increased risk of SD(p<0.05). 결론:These results suggest that SNP of LOXL2 gene closely related to affects sudden deafness risk.