Çмú´ëȸ ¹ßÇ¥ ¿¬Á¦ ÃÊ·Ï
Submission No. 200012    3 
Comparison of Click and Chirp evoked ABR
¼­¿ï´ëÇб³ Àǰú´ëÇÐ À̺ñÀÎÈİúÇб³½Ç
ÀÌÁØÈ£
The ABR (auditory brain stem response) is neural response to a certain stimulus, which is useful in evaluation of the hearing integrity in normal and hearing loss. Clinically ABR is applied in indirect estimation of hearing thresholds in adults and infants(Hecox et al., 1974) and in detection pathologies of peripheral and central nerve systems(Starr et al., 1975). A various kind of stimulus could be used to acquire ABRs. Among them click and the tone burst are the most frequently used stimulus in current clinical environments. Tone bursts are used in some circumstances due to their benefits regarding frequency specific threshold, however practically speaking its amplitudes are relatively small and need longer test time and experienced examiner is required for the tone burst ABRs. On the other hand, clicks are used relatively more often to obtain screening ABRs. Since they have of rapid onset and broad-frequency spectrum, clicks elicit larger waveform amplitude and higher neural synchrony(Don et al., 1994; Gorga et al., 2006). Though its usefulness and wide adaptation throughout the world wide clinics and hearing loss screening, there seems to be some pitfalls of click evoked ABRs. In the past, since it is produced in a wide range of frequency, it was expected to stimulate more fibers(Debruyne, 1986) to reflect all the behavioral thresholds. Despite this expectation, according to the previous studies, the strongest correlation between click ABR and pure-tone thresholds were found at 2 and 4 kHz which represents the only basal portion of the cochlea(Dau et al., 2000; Don et al., 1978). This is thought to be due to cochlear traveling way delay, which could lead to natural phase cancelations among the collective responses from individual neural unit which contributes to the ABR response(Don et al., 2005; Maloff et al., 2014). In addition, with click evoked ABRs, cochlear tonotopic region below the frequency of 1000 Hz might not be excited especially in low stimulus, near the threshold level because the waveform is likely to represent neural activity closer to 1000~4000 Hz region(Maloff et al., 2014). Reflecting these recent changes, ABRs with combination of narrow band stimulus and click is recommended by some authors not to rule out low frequency hearing losses(Gorga et al., 2006). Furthermore ¡°The Current Joint Committee on Infant Hearing (JCIH)¡± also suggested including the tone burst, which is narrow band stimuli, for screening hearing loss infants(Fobel et al., 2004). As the modality to enhance the synchrony and compensate the traveling wave delay, the chirp is designed. For the chirp stimulus, higher frequency components delayed relative to lower frequency components(Dau et al., 2000). This concept was applied to auditory electrophysiology at 1982(Harrison et al., 1982) and it is intensively studied in various kinds of auditory fields(Elberling et al., 2007). Several chirp designs have been proposed and tested over the decade. For example, Fobel and Dau reported comparison results about the O-chirp which was based on stimulus frequency otoacoustic emissions, A-chirp which was based on tone burst ABR latencies, and M-chirp which has temporal envelope starting with very small amplitudes at the low frequencies and increasing nonlinearly. Among these different chirps A-chirp was reported to have most robust amplitudes(Fobel et al., 2004). Recently a new chirp, CE-Chirp has been introduced and its result has been reported in several studies that evaluated responses from normal hearing subjects(Elberling et al., 2008; Elberling et al., 2010b; Gotsche-Rasmussen et al., 2012). The design of this chirp was based on derived band ABR latency information from normal hearing adults. One of the unique and unwanted findings in the CE-Chirp ABRs is low amplitude at high intensity level stimulus and this was also found in our study report at the IERASG 2011(Cho et al., 2011). The main reason for this drawback of the CE-Chirp is presumed to be from the upward spread of excitation and changes in cochlea-neural delay according to its stimulus levels(Elberling et al., 2010a). In LS-Chirp, which is variation from the CE-Chirp, level dependent stimuli (for example: shorter duration and longer latency for high intensity level) is equipped to compensated previous pitfalls and now this stimulus is getting ready for the clinical release. Therefore, according to the recent paradigm, we believe that LS-Chirp is the most up-to-date form among the chirp stimulus families. Regarding this LS-Chirp, authors have analyzed some unpublished preliminary data. We compared wave amplitudes and ABR thresholds from Click and LS-Chirp stimulus in normal hearing (n=7), and found out that LS-Chirp had statistically better performance in both two parameters (larger amplitudes, lower threshold difference from behavioral threshold). Also, especially in the high intensity level (70 dBnHL) LS-chirp revealed statistically higher amplitude than click evoked ABRs. There are many reports regarding the ABRs from chirp in normal hearing subjects, however reports from data acquired from hearing loss subjects are rare. Recently, Erin and Hood reported considerably stable threshold correlation to behavioral threshold using M-chirp ABRs in hearing loss subjects, and they also found that Chirp ABRs were favorable than click ABRs as for some aspect not only in normal hearing but also in hearing loss subjects(Maloff et al., 2014). We will report here in sensorineural hearing loss patients using LS-chirp. In conclusion, though click is the conventional widely applied stimulus for ABRs, a chirp stimulus was able to generates larger neural amplitude with suitable models of cochlear traveling wave delay than conventional responses (Konrad-Martin et al., 2012; Kristensen et al., 2012; Maloff et al., 2014). And it is possible that this new stimulus could be adjuvant modality to retrieve more information about the subjects hearing objectively. However further study regarding chirp ABRs is necessary for this new stimulus to replace the click ABRs, because it is not clearly understood and interpreted in certain circumstances, especially in pathologic condition (sensorineural hearing loss and central auditory pathway lesions). Reference Cho, S.W., Han, K.H., Shin, S.O., Lee, J.H. 2011. Comparison between CE-Chrip and Click evoked ABR in normal and sensorineural hearing loss. poster presentation at XXII IERASG BIENNIAL SYMPOSIUM, 2011. Dau, T., Wegner, O., Mellert, V., Kollmeier, B. 2000. Auditory brainstem responses with optimized chirp signals compensating basilar-membrane dispersion. The Journal of the Acoustical Society of America 107, 1530-40. Debruyne, F. 1986. Influence of age and hearing loss on the latency shifts of the auditory brainstem response as a result of increased stimulus rate. Audiology : official organ of the International Society of Audiology 25, 101-6. Don, M., Eggermont, J.J. 1978. Analysis of the click-evoked brainstem potentials in man unsing high-pass noise masking. The Journal of the Acoustical Society of America 63, 1084-92. Don, M., Elberling, C. 1994. Evaluating residual background noise in human auditory brain-stem responses. The Journal of the Acoustical Society of America 96, 2746-57. Don, M., Kwong, B., Tanaka, C., Brackmann, D., Nelson, R. 2005. The stacked ABR: a sensitive and specific screening tool for detecting small acoustic tumors. Audiology & neuro-otology 10, 274-90. Elberling, C., Don, M. 2008. Auditory brainstem responses to a chirp stimulus designed from derived-band latencies in normal-hearing subjects. The Journal of the Acoustical Society of America 124, 3022-37. Elberling, C., Don, M. 2010a. A direct approach for the design of chirp stimuli used for the recording of auditory brainstem responses. The Journal of the Acoustical Society of America 128, 2955-64. Elberling, C., Callo, J., Don, M. 2010b. Evaluating auditory brainstem responses to different chirp stimuli at three levels of stimulation. The Journal of the Acoustical Society of America 128, 215-23. Elberling, C., Don, M., Cebulla, M., Sturzebecher, E. 2007. Auditory steady-state responses to chirp stimuli based on cochlear traveling wave delay. The Journal of the Acoustical Society of America 122, 2772-85. Fobel, O., Dau, T. 2004. Searching for the optimal stimulus eliciting auditory brainstem responses in humans. The Journal of the Acoustical Society of America 116, 2213-22. Gorga, M.P., Johnson, T.A., Kaminski, J.R., Beauchaine, K.L., Garner, C.A., Neely, S.T. 2006. Using a combination of click- and tone burst-evoked auditory brain stem response measurements to estimate pure-tone thresholds. Ear and hearing 27, 60-74. Gotsche-Rasmussen, K., Poulsen, T., Elberling, C. 2012. Reference hearing threshold levels for chirp signals delivered by an ER-3A insert earphone. International journal of audiology 51, 794-9. Harrison, R.V., Evans, E.F. 1982. Reverse correlation study of cochlear filtering in normal and pathological guinea pig ears. Hearing research 6, 303-14. Hecox, K., Galambos, R. 1974. Brain stem auditory evoked responses in human infants and adults. Archives of otolaryngology (Chicago, Ill. : 1960) 99, 30-3. Konrad-Martin, D., Dille, M.F., McMillan, G., Griest, S., McDermott, D., Fausti, S.A., Austin, D.F. 2012. Age-related changes in the auditory brainstem response. Journal of the American Academy of Audiology 23, 18-35; quiz 74-5. Kristensen, S.G., Elberling, C. 2012. Auditory brainstem responses to level-specific chirps in normal-hearing adults. Journal of the American Academy of Audiology 23, 712-21. Maloff, E.S., Hood, L.J. 2014. A comparison of auditory brain stem responses elicited by click and chirp stimuli in adults with normal hearing and sensory hearing loss. Ear and hearing 35, 271-82. Starr, A., Achor, J. 1975. Auditory brain stem responses in neurological disease. Archives of neurology 32, 761-8.


[µ¹¾Æ°¡±â]